Tuesday, April 28, 2020
IT on Everyday Life
Introduction The information revolution was sparked in the mid 20th century, when scientists built the first programmable electronic computers. Since then, the growth of IT has become a major and significant aspect of people in their daily lives. Today, many people depend on IT either directly or indirectly. This paper critically examines how IT aspects affect our daily lives as employees, students, family members and community membersAdvertising We will write a custom essay sample on IT on Everyday Life specifically for you for only $16.05 $11/page Learn More Discussion IT and Human Survival Since IT was invented and taken to the public domain, it has become a major aspect of human survival in the world, especially in the developed world (Michael 2009). Many people have become too dependent on IT as a means of life, and this has made IT a major human need in many areas of the world. As William (2011) asserts, one way that IT has become an important comp onent of human survival is by providing efficient and cheap communication. Information has been a very important aspect of human survival for as long as human beings have existed. The communication of this information is therefore very important for individuals and communities. Today, this communication is in terms of money transfer, information sharing on social networks, and accessing official information from government agencies through online platforms such as online portals. Internet has also made it very possible for people to access jobs that are miles away from their location. Impact of E-commerce According to Mathew (2010), electronic commerce has made it possible for businesses in one area to be able to access markets that are many kilometres from their geographical locations. A good example of businesses that have been able to use e-commerce to take advantage of markets far away is Amazon, which is one of the oldest online businesses. The advantages of e-commerce are not only oriented to the businesses only, but also to the consumers (Wesley 2011). Consumers are able to easily buy directly from manufacturers, who are geographically very far from them and this means that the consumers of a product that is not produced locally, are able to enjoy the product that is produced elsewhere. Social computing As Maxwell (2009) notes, social computing has become a very easy way for people to socialize. While there are many negative things that have been attributed to social computing such as internet addiction and deterioration of real social life, social life can also be seen as a positive way for people to socialize and reach out.Advertising Looking for essay on computer science? Let's see if we can help you! Get your first paper with 15% OFF Learn More This is especially important for people who are physically disabled, since they can still meet their friends on social networks and virtual chartrooms. Research shows that many people who have l ost self esteem and are unable to freely socialize with people in the real world are able to get their esteem back if they have a social media they use, because it is easier for them to express themselves on the cyber sphere (Gerald 2009). Future of social computing The future of social computing can only be seen from a speculative point of view (Danileson 2009). There are those who believe that as time goes, more people who are unable to cope in the real world, will go online and start having virtual lives. This will therefore start affecting even those who are not deep into the virtual online world. These people argue that in future, social computing will become more acceptable and the cyber sphere will help all people live more enhanced lives. On the other hand, some argue that social computing will get out of hand and affect people negatively, by making it impossible for important social developments to occur or for people to make meaningful relationships. IT and efficiency Info rmation Technology has definitely increased efficiency in many ways in peopleââ¬â¢s lives. One thing that has benefited from IT to gain efficiency is money transfer. With the help of information technology, money transfer has been made much easier and simpler, and processes that used to take days or even weeks to complete, can today be completed in a matter of hours or minutes. Communication has also become easier and cheaper as a result of developments in IT. This can be found within organizations where networks have been used to increase efficiency in the way information is shared among various departments. Databases have brought about a new way to manage and retrieve information efficiently. Engineers now donââ¬â¢t have to go through the heavy tasks of designing models on paper using a pencil and thousands of lines. Computer Aided Design is a software-based way for such engineers to easily and efficiency produce, modify and redesign models of whatever things they are design ing, such engines, airplanes, vehicles and buildings.Advertising We will write a custom essay sample on IT on Everyday Life specifically for you for only $16.05 $11/page Learn More IT becoming a necessity Information Technology has changed how the world works, and individuals donââ¬â¢t have a choice, but to acquaint themselves with the technology. Computers have become a necessity, because to access much important information such as that from government agencies, they have to use computers. Without a computer and an internet connection, it has become very difficult for individuals to live. Most government agencies have continually moved their services into the cyber sphere and for individuals to access these services, they have to be conversant with IT. IT and student works Modern IT systems have made student work easier and better. Students are able to access a lot of information online for their research. As James (2009) points out, assignments ca n now be better researched online in the pre-IT times, unlike earlier, when the library was the only source of information. Today, with millions of web servers on the internet, including journals, blogs, electronic encyclopedia and other forms of information, a student can access information to enrich his or her assignment. With a computer, a student can produce a neat document using word processors such as MS word, and either submit this document in an electronic format or print it out using a printer. These IT systems such as computers, softwares, printers and photocopiers, have not only made the work of the student better, but also easier to manage, thus making it possible for them to produce high quality works. Disadvantages With the advent of these IT systems, it is easier for students to cheat in their work, because the students can easily copy information directly from the internet, instead of reading and synthesizing the information in order to produce their own work. As a r esult, these IT systems can also be seen as hindrances to the development of education and the quality of education that the students will gain from school. The other disadvantage of these systems is that they are only accessible if one has an internet connection and therefore, may not be useful if there is no internet connection.Advertising Looking for essay on computer science? Let's see if we can help you! Get your first paper with 15% OFF Learn More Conclusion Information Technology will continue to be a major contributor to human survival. Scientists argue that by the year 2035, IT singularity will have occurred, which means that computers and humans will be able to interact at a physiological level, and that the computers will be more intelligent than human beings. Whether that is or is not possible remains to be seen. However, the fact that IT has been a major contributor to human existence is not debatable. References Danileson, K 2009, ââ¬Å"The Way Forward for Social Media,â⬠Forum for Informaitron Technology and Socail Change, vol. 3 no. 7, pp. 29-31. Gerald, K 2009, ââ¬Å"Understanding the Social Impact of Tecnology,â⬠International Institute of Techology Review, vol. 5 no. 5, pp. 45-46. James, L 2009, ââ¬Å"How IT is changing the Lives of Ordinary People in the World,â⬠Journal of Technology, vol. 4 no. 5, pp. 45-48. Mathew, K 2010, ââ¬Å"Modern Business and the Role of Information Technology,â⬠Journal of Economics, vol. 3 no. 4, pp. 29-23. Maxwell, J 2009, ââ¬Å"Modern Infroamtion Systems,â⬠Journal of Infroamitron Technology, vol. 4 no. 7, pp. 12-13. Michael, K 2009, ââ¬Å"Understanding Modern IT Sytems,â⬠Journal of computing Technology, vol. 4 no. 8, pp. 29-31. Wesley, K 2011, ââ¬Å"Ecommerce and Infromaiton Technology,â⬠Journal of Economics, vol. 3 no. 8, pp. 34-36. William, E 2011, ââ¬Å"Understanding Modern Information Interchange,â⬠Journal of computing Technology, vol. 4 no. 7, pp. 67-69. This essay on IT on Everyday Life was written and submitted by user Rafael Vega to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.
Friday, March 20, 2020
Goiter essays
Goiter essays A goiter is often referred to as an enlargement of the thyroid gland which is not caused by inflammation or cancer. Goiter, when at a simple level, occurs when the thyroid gland can not produce enough of the thyroid hormone to meet the bodys daily requirements. As a counteraction, the thyroid gland enlarges, which usually overcomes small thyroid hormone deficiencies. A simple case like this is called either an endemic goiter or a sporadic goiter. Endemic goiters often occur within groups of people living in areas with soil with low iodine, usually regions away from the sea coast. Most people in these communities might not get enough iodine in their diet which is important for the production of the thyroid hormone. Use of iodized table salt in the U.S. prevents this; however it is still common in central Asia and central Africa. Another cause for goiter is use of the medications lithium and aminoglutethimide, used to treat some kinds of tumors that affect the adrenal cortex. Some cases of goiter are caused by hereditary factors, Most of the causes for goiter, however, are unknown to us at this time. Risk factors for the development of a goiter include female sex, age over 40 years, inadequate dietary intake of iodine, residence in an endemic area, and a family history of goiter. Goiter may be prevented by avoiding use of the medications shown above, and the use of iodized table salt, as indicated above. A few of the symptoms of goiter include any sort of thyroid enlargement, breathing difficulties due to compression of the trachea, swallowing difficulties due to the compression of the esophagus, and dizziness when arms are raised above the level of the head. There are many tests that may determine if you have goiter or not. Some of these including measurements of thyroid stimulating hormone and thyroxine in the bloodstream, a thyroid scan, and finally an ultrasound on the thyroid. ...
Tuesday, March 3, 2020
Past Simple Verb Form Example Worksheets
Past Simple Verb Form Example Worksheets The past simple takes the following forms: Past Simple Positive: Subject past simple form of verb objects Jason went to camp in Florida last week.We had dinner at that new restaurant two days ago. Past Simple Negative Form: Subject did not verb objects Mary didnt attend the meeting last week.They didnt pass the exam yesterday. Past Simple Question Form: (Question Word) did subject verb? What did you do yesterday?When did they meet Tim? Important Notes ï » ¿The verb to be does not take the auxiliary verb did in the question or negative form.The regular past simple form of verbs ends in -ed, irregular past simple form of verbs vary and must be studied. Examples I was on time to the meeting yesterday.Alexander wasnt born in April. He was born in May.Were you at the party last night? Ago / Last / In Ago is used at the end of a sentence preceded by a specific amount of time such as: three days ago, two weeks ago, one month ago, etc.Last is used with week, month, and year.In is used with specific months and years in the past. Practice Worksheet 1 Conjugate the verb in parentheses using the form indicated. In the case of questions, use the indicated subject as well. Tom _____ (visit) his mother last weekend.We _____ (not buy) that TV yesterday because it was too expensive._____ (you / be) at the meeting on Tuesday?Where _____ (Sheila / stay) in New Orleans?Alan _____ (understand) the situation two days ago.They _____ (not finish) the project on time last month.When _____ (Mary / fly) to New York?Henry _____ (read) Harry Smiths latest book last month.I _____ (not write) that letter to him last week.What _____ (you do) yesterday afternoon?You _____ (think) he couldnt win, didnt you?She _____ (not win) the prize two weeks ago.Where _____ (Andy / go) last week?Thomas _____ (come) to visit us in May.Susan _____ (not telephone) in time to get a ticket.How _____ (you meet) him?David _____ (get up) early on Saturday to play golf.Betty _____ (not draw) that picture._____ (Peter forget) his books yesterday?She _____ (give) him a present for his birthday yesterday. Practice Worksheet 2 Choose the correct time expression used with the past simple tense. Cathy left on holiday (last / ago) week.I played football (when / last) I was in high school.Were you able to go to the meeting (ago / in) May?She didnt think about those problems two days (last / ago).There werent any children at the party (last / when) Saturday.Jennifer wanted us to come and help three weeks (ago / when).Peter went to a meeting in Chicago (last / ago) Tuesday.Alexander made a number of mistakes (yesterday / tomorrow).Tom was born (at / in) 1987.Our teacher helped us understand the problem (this morning / tomorrow morning).I bought a new chair for my office (last / next) week.Did you finish the meeting on time (yesterday / last) evening?Susan visited her aunt in Seattle (last / ago) Sunday.My father took me to the zoo (when / last) I was a child.They opened a new store (in / on) Tuesday.She drove to New Mexico (in / on) February.We enjoyed a lunch with our friends (yesterday / tomorrow).Annabelle played the piano for two hours (on / in) Tuesday.Fred didnt attend the meeting (last / ago) week. Anne opened a bottle of wine two hours (ago / last). Worksheet 1 Answers Tom visited his mother last weekend.We didnt buy that TV yesterday because it was too expensive.Were you at the meeting on Tuesday?Where did Sheila stay in New Orleans?Alan understood the situation two days ago.They didnt finish the project on time last month.When did Mary fly to New York?Henry read Harry Smiths latest book last month.I didnt write that letter to him last week.What did you do yesterday afternoon?You thought he couldnt win, didnt you?She didnt win the prize two weeks ago.Where did Andy go last week?Thomas came to visit us in May.Susan didnt telephone in time to get a ticket.How did you meet him?David got up early on Saturday to play golf.Betty didnt draw that picture.Did Peter forget his books yesterday?She gave him a present for his birthday yesterday. Worksheet 2 Answers Cathy left on holiday last week.I played football when I was in high school.Were you able to go to the meeting in May?She didnt think about those problems two days ago.There werent any children at the party last Saturday.Jennifer wanted us to come and help three weeks ago.Peter went to a meeting in Chicago last Tuesday.Alexander made a number of mistakes yesterday.Tom was born in 1987.Our teacher helped us understand the problem this morning.I bought a new chair for my office last week.Did you finish the meeting on time yesterday evening?Susan visited her aunt in Seattle last Sunday.My father took me to the zoo when I was a child.They opened a new store on Tuesday.She drove to New Mexico in February.We enjoyed a lunch with our friends yesterday.Annabelle played the piano for two hours on Tuesday.Fred didnt attend the meeting last week.Anne opened a bottle of wine two hours ago.
Sunday, February 16, 2020
Critique of a Qualitative Research Paper Essay Example | Topics and Well Written Essays - 2250 words
Critique of a Qualitative Research Paper - Essay Example In addition, the researchers have particularly concentrated upon the social marketing, which looks for striving for the betterment of society at large. Social marketing, Andreasen (1995:31) submits, is the application of commercial marketing technologies to the analysis, planning, execution, and evaluation of programs designed to influence the voluntary behavior of target audiences in order to improve their personal welfare and that of their society. In other words, the main objective of the social marketing is working voluntarily for the benefit and uplift of the individuals at large. Moreover, it is also a reality that the young people are the future builders of a society, proper education and training of which is one of the most formidable responsibilities of all members of asocial set up. If the youth is not discouraged and prohibited from participating into the social evils including drinking, smoking and gambling etc, the future prospects of the society would be in grave jeopar dy for the future years of come. In addition, it has aptly been observed that gambling leads the young people towards other nefarious activities including drinking and sex etc, which may challenge their health condition. Hence the social problem, selected by the researchers, is very important in its scope and exposure, and carries wide scope and depth in its nature. The researchers are quite justified in choosing the research problem related to social marketing, which looks to strive for the wellbeing and safety of the young people on the basis of the findings of the study, as well as the suggestions made on the foundations of the findings of the present research. Whether positively or negatively the gambling prevention campaigns, being launched by the government and non-governmental organizations at various media platforms, influence the minds of the young
Sunday, February 2, 2020
Hazard of your choice Lab Report Example | Topics and Well Written Essays - 1000 words
Hazard of your choice - Lab Report Example While the centre of the storm is the calmest with light winds, the further parts of the storm are very violent. When this comes to land, it leads to heavy rains, large waves and strong winds that can damage property, land, buildings, trees, cars and result into heavy flooding leading to loss of animals and human life. The magnitudes of the impacts of hurricanes can be understood from the meteorologists ââ¬Å"Saffir-Simpson Hurricane Wind Scale.â⬠In this scale, the magnitude of hurricane is categorized in a scale of 1-5, however, this scale do not address the impacts of such magnitudes. According to Kislow (21), category one consists of winds ranging from 74-95 mph and result into minor damages to property, falling debris, limited flying and minor injuries to people and animals. Category 2 consists of winds ranging from 96 to 110 which have potential to result into heavy property damage. According to Kislow (21), this category of hurricanes consist of winds with high velocities which carry debris thus poses threat to animals, humans and significant damage to apartment buildings, mobile homes, shopping centers and result into extensive power outages. Category 3 consists of heavy winds of approximately 111 to 130 mph and can result into extensive property damage. This category of hurricane has potential of destroying even well built homes, cause extensive inland flooding and damage to electricity and water sources and lines. Category 4 hurricane consists of winds ranging from 131 to 155 mph and can cause serious catastrophic damage to humans, property and animals. As stated by Vecchi et al (5341), it can cause significant catastrophic damage to apartments, frame homes, as well as shopping centers and include long term water shortages and power outages of up to few months. Category five consists of winds that ranges from 131 to 155 mph and can course complete destruction to property, apartments, trees, shopping malls, and land. It is also important
Saturday, January 25, 2020
Effect of Medicinal Plant Extracts on Alzheimers Disease
Effect of Medicinal Plant Extracts on Alzheimers Disease Alzheimerââ¬â¢s disease (AD) is a neurodegenerative disease which causes a lethal twist in the structural integrity, and a roadblock in the function of brain, this eventually channel the situation to degeneration and shrinkage of brain, and override the control of brain over other parts of the body, and comes to the final closing remark of the disease- death. Studies done on the topic have corroborated that the disease is not reversible, and the only patch of hope is slowing down its progress. But as the disease advances through mid stage and evolves into severe AD, the condition of patient becomes pathetic and care giving becomes more painful. Studies have reported that notable symptoms of AD are seen only after 60 years of age, even though the disease has started before that. Initial symptoms are loss of short term memory- being forgetful about the recent events, and gradually over a period of time patient seems more absent ââ¬âminded about the environment, things which are chemically etched in the long term memory begins to be erased, and the final stage starts pushing the patient into severe AD which is tremendously pathetic. Studies have proved that loss of function of neurons is the cause of AD. A closer look into the aspect revealed a complex set of events that precede the neuronal degeneration- oxidative stress and imbalance in homeostasis, formation of roadblocks in communication, falling apart of integrity and death of neurons. This enabled to go beyond the findings of superficial studies done and hypothesis developed, and helped to delve much deeper into the inner workings and mechanism of the disease. Hypotheses developed to explain mechanism of AD are: amyloid cascade hypothesis, cholinergic hypothesis and tau hypothesis. Amyloid cascade hypothesis says, APP- Amyloid Precursor Protein, a transmembrane protein involved in main roles of growth, survival and repair of nerve cells- is snipped at wrong places by an enzyme called secretase, leading to the formation of amyloid à ² peptides which accumulates to form plaques- amyloid plaques- and bind to synapses blocking the communication channel, event ually causes memory loss. According to cholinergic hypothesis, downward drift in the levels of acetylcholine in brain is the cause for Alzheimerââ¬â¢s disease. Loss of function of cholinergic neurons was found in Alzheimerââ¬â¢s disease patients. Shift in the level of acetylcholine happens due to the lack of two enzymes involved in synthesis and breaking down of acetylcholine. This will lead to loss of function of neurons; brainââ¬â¢s functionality falls apart, and eventually leads to symptoms of Alzheimerââ¬â¢s disease. Tau hypothesis approaches the problem in another perspective, tau protein- a protein associated with microtubules in nerve cells- gets hyperphosphorylated, this enables cross linking among tau protein units, and they back off from being attached to the microtubules. This causes loss of structural integrity of nerve cells, and they collapse and clump to form tangles- neurofibrillary tangles. Studies conducted focusing on the inner workings of these hypoth esis have found that oxidative stress is the reason that enhances plaque and tangle formation, repair mechanisms in cells are unable to solve the situation as the oligomer formation and cross linking are predominantly made by non peptide bonds. In another study, amyloid à ² peptides have shown close relation with some causes of mad cow disease. Studies related to genetics of AD have found the link between APOE gene on chromosome 21 and the disease. APOE gene codes for apolipoprotein, and one among its functions is breaking down of APP. APOE has variants, APOEà µ4 is the one which codes for less active protein whose capacity to break down APP is sluggish. People with this variant gene are more tend to develop AD in later stages of life, and any abnormality related to chromosome 21 also results in AD over a period of time. To know more about the mechanism of disease and its attachment to oxidative stress, further studies have done from different angles, and all the studies have come to a common point, the findings from all the studies stitched together gave a complex and elaborate picture about the mechanism of the disease. Free radical damage leads to oxidation of products in cell. Oxidation leads to new end products of glycation, nitration, lipid peroxidation, and oxidation of nucleic acids. These new end products chemically modify other proteins and compartments inside the cell. Oxidized derivatives impede with the channel of trace elements, and imbalances their homeostasis, and enables proteins like tau to form non peptide cross linking. In response to changes cell up the levels of heme oxygenase-1 (HO-1)- an antioxidant enzyme to mitigate the bad effects from free radical damage- but rapid heaping up of neurotoxic substances goes beyond control leading to severe imbalances, blockage of communicati on channels, and eventually death of neuron. Since mitochondria is the main source of free radicals and oxidative precursors. Certain deletions in mtDNA resulted in change in normal levels and rates of metabolism and production of free radicals. Free radicals formed in mitochondria are short lived and they do not have the ability to cross membrane and reach cytoplasm to cause damage, this led studies in a new direction and found free radicals- OH from cytoplasm- can attack guanidine in RNAs in cytoplasm and this both can cross the membrane and reach into mitochondria, and cause imbalance and production of more stable H2O2 radicals which can come to cytoplasm and react with the channel of trace elements, and starts the primary events for the major causes for AD to come into being. AD starts at neocortex area of brain, and as the neurons die and rupture, the neurotoxic substances- plaques, free radicals, tangles, etc. pervade the nearby nerve cells, and the cycle goes on and graduall y covers the brain and makes it slip out of its normal being. Oxidative stress in brain leads to degeneration of neurons, which eventually leads to dementia, and Alzheimerââ¬â¢s disease (AD). This oxidative stress in brain can be slowed down or reversed- to a small extent- using drugs to treat AD or using antioxidant capacity of some medicinal plants. In this study rats were arranged into seven groups, and different groups were treated with different plant extracts and rivastigmine. AD was induced using aluminum chloride- rats were given aluminum chloride for one month, and the dosage was 17mg/kg of body weight. One group was kept as control- healthy control and another group as AD-induced. Rivastigmine was given to group 3. Group 4 and 5 were treated with extracts of a medicinal plant- Salvia triloba; and group 6 and 7 were treated with extract made from Piper nigrum. The rats were given drug and extracts for three months. At the end of three months duration biochemical assays and histopathology was done to examine the changes happened to t he brains. The following things were checked for in serum: malondialdehyde, total antioxidant capacity and nitric oxide, and level of superoxide dismutase were checked in erythrocytes. Acetylcholine and acetylcholine esterase levels were checked in brain samples and another group of brain samples were given for histopathology. From the results, the rats which were treated with Piper nigrum extract and rivastigmine showed increase in brain Ach, and serum TAC and SOD; and a significant decrease in brain AchE, and serum MDA and NO. The rats which were treated with extract of Salvia triloba showed even better result in subduing the oxidative stress to a certain limit. Antioxidant capacity of plants was used to bring down the effects of oxidative stress in brain. Here, the effect of the extract made from Boswellia serrata is compared with rivastigmine on rats with AD- induced by oral administration of aluminum chloride. Ninety male rats were used in the study. They were made into nine groups. Group 1 was kept as healthy control, group 2 was given with aluminum chloride for four weeks, and group 3 was treated with rivastigmine, group 4 and 5 were treated with two different concentrations of plant extract made from Boswellia serrata. Groups 3 to 5 were treated with a combination of aluminum chloride and other things to check the ability of extract and drugs to protect the brain from the stress. Group 6 was given with water after inducing AD. Group 7 was given with rivastigmine, and group 8 and 9 were given with two different concentrations of plant extract- this was done for twelve weeks. Cognitive tests were done at the beginning of each new stage o f the study. At the end of the duration of the study, the brain samples were subjected to biochemical assays and histopathology. From the results, B.serrata has significant ability to reduce the oxidative stress in brain, and higher dose if the extract showed better effect- bringing down the severity of oxidative stress damage. Bacopa monnieri is another plant used to trim the effects of AD. This plant is used since ancient times for improving intelligence, and in this study its ability to protect against AD is checked. Alcoholic extracts of the plant was made for the study. AD was induced using ethylcholine aziridinium ion (AF64A)- administered intracerebroventricular way bilaterally. Plant extract was given to the rats two weeks before and one week after the administration of AF64A. rats were subjected to cognitive tests. Rats treated with the plant extract cleared the tests in less time. Histopathology results showed, low dose of the plant extract brought down the degree of damage in brain- reduction of neurons density. Low dose showed better result compared to the medium and high dose. The study has not revealed the mechanism of action of the plant extract, but it showed the scope for a further study on the same. Targeted drug delivery to brain in case of Alzheimerââ¬â¢s disease is more complex process due to many factors like blood brain barrier and actions of plasma proteins. But nanoparticles are used for targeted drug delivery, and this is again affected by physiochemical properties of Nanoparticles in different surfactants, stability of nanoparticles and organic coating or capping agent on nanoparticles. Blood brain barrier is a homeostatic defense mechanism used by brain to screen out pathogens and unwanted materials from entering brain. The barrier screens the solutes biochemically, physicochemically and structurally at the periphery. There are times when blood brain barrier breaks down due to certain infections or due to any physical reason, and this makes it skew from its usual nature- highly selectively permeable. Studies have been conducted to find how nanoparticles are treated at blood brain barrier. In a study, nanoparticles were made by warm microemulsion precursors, and the nanoparticles were radiolabelled by entrapment. Then an in situ study was conducted to check how nanoparticles cross the blood brain barrier. From the study it was concluded that endocytosis or transcytosis as possible mechanism for the transport across the barrier- more studies are yet to be conducted. Studies have shown that clioquinol- a quinoline derivative- can solubilize amyloid à ² plaques in vitro and this could prevent accumulation of amyloid à ² plaques in Alzheimerââ¬â¢s disease transgenic mice- an in vivo study. Clioquinol has shown its ability to dissolve plaques which are induced by Zn and Cu ions- NMR studies have shown that clioquinol can remove bound Cu ions from amyloid à ² plaques. The study conducted has overlooked the toxicity part of clioquinol- though clioquinol has many side effects attached to it at high doses. It has shown in the later part of the study that clioquinol coupled with nanoparticles could easily cross the blood brain barrier- higher degre e of uptake by brain. So, clioquinol-nanoparticle delivery system is suggested to be considered as one among the models for treating Alzheimerââ¬â¢s disease by targeted drug delivery. Even though using nanoparticles are considered for drug delivery, there are studies showing the side effects, and doses. In a study- toxicity of silver nanoparticles- it was found that exposure to more than 125mg/kg of silver nanoparticles will lead to liver damage due to toxicity. In a study curcumin nanoparticle formulation was used to test its effect on Alzheimerââ¬â¢s disease in mice. Nanocurcumin was synthesized and orally given to the mice for twelve days. Memory tests were done before starting every new stage of the experiment. Results have shown that mice treated with nanocurcumin could clear the cognitive tests- significant improvements were observed.
Friday, January 17, 2020
How to Address Conflicts or Dilemmas Essay
1.1Describe potential conflicts or dilemmas that may arise between the duty of care and an individual`s rights. In our care work we mostly work with children and young people who may not have the ability to judge what is good for them and what is not. In those cases it is our responsibility and job as individuals and as a team to provide them what we judge is best for them. In some other cases they have the skills to get involved in the decisions and this can lead to conflicts and dilemmas. Potential conflicts between the service user and the care worker in our job role can arise from disagreeing in certain questions e.g. what is healthy to eat, what is not, what is more important when having a meal: quality or quantity, what activities or forms of entertainment (films, songs, etc.) are age-appropriate and/or mentally and emotionally adequate and so on. 1.2Describe how to manage risks associated with conflicts or dilemmas between an individual`s rights and the duty of care. If a conflict arises, I can never force a learner to do or not to do things unless the law or the School Policy allows me to (for example if they want to watch an age-inappropriate film, but in these cases I always have to refer to my line manager). What I can do if a conflict in these questions arises between me and the learner is to provide all the information about the risk carried by their decisions in a supportive, encouraging way, and then let them make their own choices. Every time when a conflict arises I should record what actions were taken to provide every source for the learner to make their own decision and what choice they made. I always should seek for advice at my line manager.
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